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The Department of Maxillofacial Tissue Regeneration was founded since the Research Center for Tooth and Periodontal Tissue Regeneration (RCTPTR) was launched in Sept 2011 with an MRC grant supported by the Ministry of Education, Science, and Technology. The goal of the MRC is to search the mechanism of the damage and destruction of dental and periodontal tissue, to secure a fundamental technology for tooth and bone regeneration via the discovery and evaluation of regenerative lead-compounds and materials using target genes, natural compounds and tissue engineering. Furthermore, our research center designed to nurture basic research scientists who were trained as dentists, contributing to the globalization of dental medicine.